Rethinking Meat in Our Diet: The Case Against Its Role in Health

Authors

  • Melaku Tafese Awulachew *

    Food Science and Nutrition Research Sector, Kulumsa Agricultural Research Center, Ethiopian Institute of

    Agricultural Research, P. O. Box: 2003, Addis Ababa, Ethiopia

DOI:

https://doi.org/10.55121/fds.v2i2.316

Keywords:

Cancer, Cardiovascular Disease, Food Matrix, Human Health, Meat, Nutrients, Recent Meta-Analyses

Abstract

Meat is a rich source of essential nutrients, including high-quality protein, bioavailable iron, zinc, and vitamin B12—nutrients often limited in plant-based diets. However, growing concerns surround the health impacts of meat consumption, particularly industrially processed meats that contain preservatives such as nitrates, nitrites, and high levels of sodium. These compounds have been associated with increased risks of hypertension, colorectal cancer, and other chronic diseases. In contrast, traditional processing methods like fermentation may enhance meat's nutritional value by promoting beneficial microbiota and producing bioactive compounds with potential health benefits. The role of saturated fatty acids (SFAs) in meat remains controversial. While historically linked to cardiovascular disease and type 2 diabetes, recent meta-analyses suggest inconsistent associations, challenging the assumption of a direct causal relationship. These findings point to the importance of considering the broader dietary context, food matrix interactions, and lifestyle factors. This narrative review critically examines current evidence on the health effects of meat consumption, with a focus on saturated fat content, processing techniques, and dietary patterns. Considerable heterogeneity exists across studies, partly due to variations in methodology, population demographics, and confounding variables such as cooking methods and food combinations. The review identifies key research gaps and underscores the need for well-controlled studies that consider these contextual factors. Ultimately, a nuanced understanding of meat’s role in human health is essential for developing balanced dietary recommendations. Future research should aim to refine public health guidance by integrating insights from nutritional science, food technology, and epidemiology.

References

[1] Tieland, M., Borgonjen-Van den Berg, K.J., van Loon, L.J., et al., 2012. Dietary protein intake in community-dwelling, frail, and institutionalized elderly people: Scope for improvement. European Journal of Nutrition. 51, 173–179.

[2] Nordic Council of Ministers, 2014. Nordic Nutrition Recommendations 2012: Integrating Nutrition and Physical Activity. Nordic Co-Operation: Copenhagen, Denmark.

[3] Wyness, L., Weichselbaum, E., O’Connor, A., et al., 2011. Red meat in the diet: An update. Nutrition Bulletin. 36(1), 34–77.

[4] Geiker, N.R.W., Bertram, H.C., Mejborn, H., et al., 2021. Meat and Human Health—Current Knowledge and Research Gaps. Foods. 10(7), 1556. DOI: https://doi.org/10.3390/foods10071556

[5] Mozaffarian, D., Rosenberg, I., Uauy, R., 2018. History of modern nutrition science—Implications for current research, dietary guidelines, and food policy. BMJ. 361, k2392. DOI: https://doi.org/10.1136/bmj.k2392

[6] FAO, 2010. Fats and fatty acids in human nutrition: Report of an expert consultation. Food and Agriculture Organization of the United Nations: Rome, Italy.

[7] U.S. Department of Agriculture, 2025. NAL Thesaurus and Glossary Home. File Name: Web Page, url: https://agclass.nal.usda.gov/agt.shtml (Metadata Updated on April 21, 2025).

[8] Rousseau, S., Kyomugasho, C., Celus, M., et al., 2019. Barriers impairing mineral bioaccessibility and bioavailability in plant-based foods and the perspectives for food processing. Critical Reviews in Food Science and Nutrition. 60(5), 826–843. DOI: https://doi.org/10.1080/10408398.2018.1552243

[9] West, E.C., Castenmiller, J.J., 1998. Quantification of the “SLAMENGHI” factors for carotenoid bioavailability and bioconversion. International Journal for Vitamin and Nutrition Research. 68(6), 371–377.

[10] Czerwonka, M., Tokarz, A., 2017. Iron in red meat–friend or foe. Meat Science. 123, 157–165. DOI: https://doi.org/10.1016/j.meatsci.2016.09.012

[11] Weinborn, V., Valenzuela, C., Olivares, M., et al., 2017. Prebiotics increase heme iron bioavailability and do not affect non-heme iron bioavailability in humans. Food & Function. 8(5), 1994–1999.

[12] Hurrell, R.F., Reddy, M.B., Juillerat, M., et al., 2006. Meat protein fractions enhance nonheme iron absorption in humans. Journal of Nutrition. 136(11), 2808–2812. DOI: https://doi.org/10.1093/jn/136.11.2808

[13] Kristensen, M.B., Hels, O., Morberg, C., et al., 2005. Pork meat increases iron absorption from a 5-day fully controlled diet when compared to a vegetarian diet with similar vitamin C and phytic acid content. British Journal of Nutrition. 94(1), 78–83.

[14] Saletti, A., Lindgren, E.Y., Johansson, L., et al., 2000. Nutritional status according to mini nutritional assessment in an institutionalized elderly population in Sweden. Gerontology. 46(3), 139–145. DOI: https://doi.org/10.1159/000022149

[15] Schulz, C., Engel, U., Kreienberg, R., et al., 2007. Vitamin A and β-carotene supply of women with Gemini or short birth intervals: A pilot study. European Journal of Nutrition. 46, 1–11. DOI: https://doi.org/10.1007/s00394-006-0623-x

[16] Boelsma, E., Hendriks, H.F., Roza, L., 2001. Nutritional skin care: Health effects of micronutrients and fatty acids. American Journal of Clinical Nutrition. 73(5), 853–864. DOI: https://doi.org/10.1093/ajcn/73.5.853

[17] Bravata, D.M., Sanders, L., Huang, J., et al., 2003. Efficacy and safety of low-carbohydrate diets: A systematic review. Jama. 289(14), 1837–1850. DOI: https://doi.org/10.1001/jama.289.14.1837

[18] Brubacher, D., Moser, U., Jordan, P., 2000. Vitamin C concentrations in plasma as a function of intake: A meta-analysis. International Journal for Vitamin and Nutrition Research. 70(5), 226–237. DOI: https://doi.org/10.1024/0300-9831.70.5.226

[19] Block, G., Norkus, E., Hudes, M., et al., 2001. Which plasma antioxidants are most related to fruit and vegetable consumption? American Journal of Epidemiology. 154(12), 1113–1118. DOI: https://doi.org/10.1093/aje/154.12.1113

[20] Danish Food Database, 2020. Frida Food Data. Available from: https://frida.fooddata.dk (cited 2 September 2020).

[21] Wood, J.D., Enser, M., Fisher, A.V., et al., 2008. Fat deposition, fatty acid composition and meat quality: A review. Meat Science. 78(4), 343–358. DOI: https://doi.org/10.1016/j.meatsci.2007.07.019

[22] Burnett, D.D., Legako, J.F., Phelps, K.J., et al., 2020. Biology, strategies, and fresh meat consequences of manipulating the fatty acid composition of meat. Journal of Animal Science. 98(2), skaa033. DOI: https://doi.org/10.1093/jas/skaa033

[23] Vahmani, P., Ponnampalam, E.N., Kraft, J., et al., 2020. Bioactivity and health effects of ruminant meat lipids. Meat Science. 165, 108114. DOI: https://doi.org/10.1016/j.meatsci.2020.108114

[24] Sandoval-Insausti, H., Pérez-Tasigchana, R.F., López-García, E., et al., 2016. Macronutrients intake and incident frailty in older adults: A prospective cohort study. Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 71(10), 1329–1334. DOI: https://doi.org/10.1093/gerona/glw033

[25] Valenzuela, P.L., Mata, F., Morales, J.S., et al., 2019. Does beef protein supplementation improve body composition and exercise performance? A systematic review and meta-analysis of randomized controlled trials. Nutrients. 11(6), 1429. DOI: https://doi.org/10.3390/nu11061429

[26] Hodgkinson, S.M., Montoya, C.A., Scholten, P.T., et al., 2018. Cooking conditions affect the true ileal digestible amino acid content and digestible indispensable amino acid score (DIAAS) of bovine meat as determined in pigs. Journal of Nutrition. 148(10), 1564–1569. DOI: https://doi.org/10.1093/jn/nxy153

[27] Buffière, C., Gaudichon, C., Hafnaoui, N., et al., 2017. In the elderly, meat protein assimilation from rare meat is lower than that from meat that is well done. American Journal of Clinical Nutrition. 106(4), 1257–1266. DOI: https://doi.org/10.3945/ajcn.117.158816

[28] Wu, G., 2020. Important roles of dietary taurine, creatine, carnosine, anserine and 4-hydroxyproline in human nutrition and health. Amino Acids. 52(3), 329–360.

[29] Meslier, V., Laiola, M., Roager, H.M., et al., 2020. Mediterranean diet intervention in overweight and obese subjects lowers plasma cholesterol and causes changes in the gut microbiome and metabolome independently of energy intake. Gut. 69(7), 1258–1268. DOI: https://doi.org/10.1136/gutjnl-2019-320438

[30] Kalpalathika, P.V.M., Clark, E.M., Mahoney, A.W., 1991. Heme iron content in selected ready-to-serve beef products. Journal of Agricultural and Food Chemistry. 39(6), 1091–1093. DOI: https://doi.org/10.1021/jf00006a020

[31] Pan, A., Sun, Q., Bernstein, A.M., et al., 2012. Red meat consumption and mortality: Results from 2 prospective cohort studies. Archives of Internal Medicine. 172(7), 555–563. DOI: https://doi.org/10.1001/archinternmed.2011.2287

[32] Cenci-Goga, B.T., Karama, M., Hadjichralambous, C., et al., 2020. Is EU regulation on the use of antioxidants in meat preparation and in meat products still cutting edge? European Food Research and Technology. 246, 661–668. DOI: https://doi.org/10.1007/s00217-020-03432-z

[33] Flores, J., Toldrá, F., 1993. Curing: Processes and applications. In: MACRAE, R. et al. Encyclopedia of Food Science, Food Technology and Nutrition. London: Academic Press, 1993. 1277-1282.

[34] Toldrá, F., 2017. The Storage and Preservation of Meat: III—Meat Processing. In: Toldrá, F. (ed.). Lawrie’s Meat Science. Elsevier: Amsterdam, Netherlands. pp. 265–296.

[35] Thøgersen, R., Castro-Mejía, J.L., Sundekilde, U.K., et al., 2018. Ingestion of an inulin-enriched pork sausage product positively modulates the gut microbiome and metabolome of healthy rats. Molecular Nutrition & Food Research. 62(19), 1800608. DOI: https://doi.org/10.1002/mnfr.201800608

[36] Pérez-Burillo, S., Pastoriza, S., Gironés, A., et al., 2020. Potential probiotic salami with dietary fiber modulates metabolism and gut microbiota in a human intervention study. Journal of Functional Foods. 66, 103790. DOI: https://doi.org/10.1016/j.jff.2020.103790

[37] Le Leu, R.K., Winter, J., Christophersen, C.T., et al., 2015. Butyrylated starch intake can prevent red meat-induced O6-methyl-2-deoxyguanosine adducts in human rectal tissue: A randomised clinical trial. British Journal of Nutrition. 114(2), 220–230. DOI: https://doi.org/10.1017/S0007114515001750

[38] Corpet, D.E., Pierre, F., 2003. Point: From animal models to prevention of colon cancer. Systematic review of chemoprevention in Min mice and choice of the model system. Cancer Epidemiology Biomarkers & Prevention. 12(5), 391–400.

[39] Da Cruz, R.M., Vieira, M.M., 2017. Mediterranean Foods: Composition and Processing. CRC Press: Boca Raton, FL, USA.

[40] Marušić, N., Aristoy, M.C., Toldrá, F., 2013. Nutritional pork meat compounds as affected by ham dry-curing. Meat Science. 93(1), 53–60. DOI: https://doi.org/10.1016/j.meatsci.2012.08.005

[41] Ruiz, J., García, C., Díaz, M.C., et al., 1999. Dry cured Iberian ham non-volatile components as affected by the length of the curing process. Food Research International. 32(9), 643–651. DOI: https://doi.org/10.1016/S0963-9969(99)00142-8

[42] Koopman, R., Crombach, N., Gijsen, A.P., et al., 2009. Ingestion of a protein hydrolysate is accompanied by an accelerated in vivo digestion and absorption rate when compared with its intact protein. American Journal of Clinical Nutrition. 90(1), 106–115. DOI: https://doi.org/10.3945/ajcn.2009.27474

[43] Toldrá, F., Reig, M., Aristoy, M.C., et al., 2018. Generation of bioactive peptides during food processing. Food Chemistry. 267, 395–404. DOI: https://doi.org/10.1016/j.foodchem.2017.06.119

[44] Moughan, P.J., Fuller, M.F., Han, K.S., et al., 2007. Food-derived bioactive peptides influence gut function. International Journal of Sport Nutrition and Exercise Metabolism. 17(s1), S5–S22. DOI: https://doi.org/10.1123/ijsnem.17.s1.s5

[45] Mora, L., Escudero, E., Arihara, K., et al., 2015. Antihypertensive effect of peptides naturally generated during Iberian dry-cured ham processing. Food Research International. 78, 71–78. DOI: https://doi.org/10.1016/j.foodres.2015.11.005

[46] Fernández, M., Benito, M.J., Martín, A., et al., 2016. Influence of starter culture and a protease on the generation of ACE-inhibitory and antioxidant bioactive nitrogen compounds in Iberian dry-fermented sausage “salchichón”. Heliyon. 2(3), e00093. DOI: https://doi.org/10.1016/j.heliyon.2016.e00093

[47] Woltman, T., Castellanos, D., Reidelberger, R., 1995. Role of cholecystokinin in the anorexia produced by duodenal delivery of oleic acid in rats. American Journal of Physiology. 269(6), R1420–R1433. DOI: https://doi.org/10.1152/ajpregu.1995.269.6.R1420

[48] Talon, R., Leroy, S., 2014. FERMENTED FOODS | Fermented Meat Products and the Role of Starter Cultures. In: Batt, C.A., Tortorello, M.L. (eds.). Encyclopedia of Food Microbiology, 2nd ed. Academic Press: New York, USA. pp. 870–874. DOI: https://doi.org/10.1016/B978-0-12-384730-0.00116-6

[49] Klingberg, T., Budde, B., 2006. The survival and persistence in the human gastrointestinal tract of five potential probiotic lactobacilli consumed as freeze-dried cultures or as probiotic sausage. International Journal of Food Microbiology. 109(1–2), 157–159. DOI: https://doi.org/10.1016/j.ijfoodmicro.2006.01.021

[50] De Vuyst, L., Falony, G., Leroy, F., 2008. Probiotics in fermented sausages. Meat Science. 80(1), 75–78. DOI: https://doi.org/10.1016/j.meatsci.2008.05.038

[51] Inguglia, E.S., Zhang, Z., Tiwari, B.K., et al., 2017. Salt reduction strategies in processed meat products – A review. Trends in Food Science & Technology. 59, 70–78. DOI: https://doi.org/10.1016/j.tifs.2016.10.016

[52] Carrascal, J.R., 2016. Cured foods: Health effects. In: Caballero, B., Finglas, P., Toldrá, F. (eds.). Encyclopedia of Food and Health. Elsevier: Amsterdam, Netherlands. pp. 338–342.

[53] Händel, M.N., Cardoso, I., Rasmussen, K.M., et al., 2019. Processed meat intake and chronic disease morbidity and mortality: An overview of systematic reviews and meta-analyses. PLoS ONE. 14(10), e0223883. DOI: https://doi.org/10.1371/journal.pone.0223883

[54] Schwingshackl, L., Schwedhelm, C., Hoffmann, G., et al., 2017. Food groups and risk of hypertension: A systematic review and dose-response meta-analysis of prospective studies. Advances in Nutrition. 8(6), 793–803. DOI: https://doi.org/10.3945/an.117.017178

[55] Lippi, G., Mattiuzzi, C., Sanchis-Gomar, F., 2015. Red meat consumption and ischemic heart disease. A systematic literature review. Meat Science. 108, 32–36.

[56] Cui, K., Liu, Y., Zhu, L., et al., 2019. Association between intake of red and processed meat and the risk of heart failure: A meta-analysis. BMC Public Health. 19, 1–8.

[57] Neuenschwander, M., Ballon, A., Weber, K.S., et al., 2019. Role of diet in type 2 diabetes incidence: Umbrella review of meta-analyses of prospective observational studies. BMJ. 366, l2368. DOI: https://doi.org/10.1136/bmj.l2368

[58] World Cancer Research Fund International, 2018. Meat, Fish and Dairy Products and the Risk of Cancer. World Cancer Research Fund International: London, UK.

[59] Cuparencu, C., Praticó, G., Hemeryck, L.Y., et al., 2019. Biomarkers of meat and seafood intake: An extensive literature review. Genes & Nutrition. 14, 1–30.

[60] Cuparencu, C., Rinnan, Å., Dragsted, L.O., 2019. Combined markers to assess meat intake—Human metabolomic studies of discovery and validation. Molecular Nutrition & Food Research. 63(17), 1900106. DOI: https://doi.org/10.1002/mnfr.201900106

[61] Cosgrove, M., Flynn, A., Kiely, M., 2005. Consumption of red meat, white meat and processed meat in Irish adults in relation to dietary quality. British Journal of Nutrition. 93(6), 933–942.

[62] Mejborn, H., Biltoft-Jensen, A., Hansen, M., et al., 2016. Mechanisms Behind Cancer Risks Associated with Consumption of Red and Processed Meat. National Food Institute: Søborg, Denmark.

[63] Mejborn, H., Kørup, K., Biltoft-Jensen, A., 2019. Food and Nutrient Characteristics of 15–75 Year Old Danes—Healthy or Unhealthy Diets with Different Meat Content. National Food Institute: Kgs Lyngby, Denmark.

[64] Chao, A., Thun, M.J., Connell, C.J., et al., 2005. Meat consumption and risk of colorectal cancer. Jama. 293(2), 172–182. DOI: https://doi.org/10.1001/jama.293.2.172

[65] Wang X, Lin X, Ouyang YY, et al., 2015. Red and processed meat consumption and mortality: dose–response meta-analysis of prospective cohort studies. Public Health Nutrition. 19(5):893–905. doi:10.1017/S1368980015002062.

[66] van Vliet S, Kronberg SL, Provenza FD, 2020. Plant-based meats, human health, and climate change. Front Sustain Frontiers in Sustainable Food Systems. 4:128. doi:10.3389/fsufs.2020.00128.

[67] Cheon, M., Chung, M., Park, Y., 2021. Association between Dietary Intake of Flavonoids and Cancer Recurrence among Breast Cancer Survivors. Nutrients. 13(9), 3049. https://doi.org/10.3390/nu13093049.

[68] Brondel, L., Quilliot, D., Mouillot, T., et al., 2022. Taste of Fat and Obesity: Different Hypotheses and Our Point of View. Nutrients, 14(3), 555. https://doi.org/10.3390/nu14030555.

[69] Gómez, I., Janardhanan, R., Ibañez, F. C., Beriain, M. J., 2020. The Effects of Processing and Preservation Technologies on Meat Quality: Sensory and Nutritional Aspects. Foods, 9(10), 1416. https://doi.org/10.3390/foods9101416

[70] Smeuninx, B., Greig, CA., Breen, L., 2020. Amount, Source and Pattern of Dietary Protein Intake Across the Adult Lifespan: A Cross-Sectional Study. Frontiers in Nutrition. 7(25). doi: 10.3389/fnut.2020.00025.

[71] Delaney, T., Jackson, J., Lecathelinais, C., et al., 2023. Exploratory analysis of a cluster randomized controlled trial of a multi-strategy intervention delivered via online canteens on improving the nutritional quality of primary school students’ pre-ordered foods & drinks at recess. Appetite. 185(2023):106528. https://doi.org/10.1016/j.appet.2023.106528.

[72] Raziani, F., Ebrahimi, P., Engelsen, S.B., et al., 2018. Consumption of regular-fat vs reduced-fat cheese reveals gender-specific changes in LDL particle size—a randomized controlled trial. Nutrition & Metabolism. 15, 1–10.

[73] Delgado, J., Ansorena, D., Van Hecke, T., et al., 2021. Meat lipids, NaCl and carnitine: Do they unveil the conundrum of the association between red and processed meat intake and cardiovascular diseases? Invited Review. Meat Science. 171, 108278. DOI: https://doi.org/10.1016/j.meatsci.2020.108278

[74] Ward, H.A., Norat, T., Overvad, K., et al., 2016. Pre-diagnostic meat and fibre intakes in relation to colorectal cancer survival in the European Prospective Investigation into Cancer and Nutrition. British Journal of Nutrition. 116(2), 316–325. DOI: https://doi.org/10.1017/S0007114516001859

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